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I. Embryology
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7. The Notochord
The notochord (Fig. 19) consists of a rod of cells situated on the ventral aspect of the neural tube; it constitutes the foundation of the axial skeleton, since around it the segments of the vertebral column are formed. Its appearance synchronizes with that of the neural tube. On the ventral aspect of the neural groove an axial thickening of the entoderm takes place; this thickening assumes the appearance of a furrow—the chordal furrow—the margins of which come into contact, and so convert it into a solid rod of cells—the notochord—which is then separated from the entoderm. It extends throughout the entire length of the future vertebral column, and reaches as far as the anterior end of the mid-brain, where it ends in a hook-like extremity in the region of the future dorsum sellæ of the sphenoid bone. It lies at first between the neural tube and the entoderm of the yolk-sac, but soon becomes separated from them by the mesoderm, which grows medial-ward and surrounds it. From the mesoderm surrounding the neural tube and notochord, the skull and vertebral column, and the membranes of the brain and medulla spinalis are developed.   1


FIG. 19– Transverse section of a chick embryo of forty-five hours’ incubation. (Balfour.) (See enlarged image)
 


 

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About USMLE

The United States Medical Licensing Examination (USMLE) is a three-step examination for medical licensure in the United States. The Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME) sponsors USMLE.
The Three Steps of the USMLE
Step 1 tests the important concepts of basic sciences basic to the practice of medicine. It also places special emphasis on principles and mechanisms underlying health, disease, and modes of therapy. Step 1 ensures mastery of the sciences that provide a foundation for the safe and competent practice of medicine. It also tests the scientific principles required for maintenance of competence through lifelong learning.
Step 2 CK tests the medical knowledge, skills, and understanding of clinical science essential for the provision of patient care under supervision. It also includes emphasis on health promotion and disease prevention. Step 2 CK ensures that due attention is devoted to principles of clinical sciences and basic patient-centered skills.
Step 2 CS tests your capacity to practice and provide good medical service in real-life situations. It also tests your communication skills.
Step 3 tests your medical knowledge and understanding of biomedical and clinical science essential for the unsupervised practice of medicine. Step 3 provides a final assessment of physicians assuming independent responsibility for delivering general medical care.